Is Kidney Stones Genetic?
Kidney stones are hard mineral deposits that form inside the kidneys. Genetic factors influence calcium, oxalate, and uric acid handling in the kidney, affecting stone formation risk.
Affects ~1 in 10 people in their lifetime.
Genetic Factors Behind Kidney Stones
Research has identified multiple genetic variants that influence a person's susceptibility to Kidney Stones. While no single gene determines whether someone will develop this condition, specific variants can increase or decrease risk. Key genes studied in relation to Kidney Stones include:
CLDN14SLC7A9ALPLUMODCLDN14CLDN14 has been associated with kidney stones in genetic studies; as with most common variants, its individual effect is modest and works alongside many other genetic and non-genetic factors.
SLC7A9SLC7A9 has been associated with kidney stones in genetic studies; as with most common variants, its individual effect is modest and works alongside many other genetic and non-genetic factors.
ALPLALPL has been associated with kidney stones in genetic studies; as with most common variants, its individual effect is modest and works alongside many other genetic and non-genetic factors.
UMODUMOD has been associated with kidney stones in genetic studies; as with most common variants, its individual effect is modest and works alongside many other genetic and non-genetic factors.
How GenomeInsight Analyzes Your Risk
GenomeInsight examines your raw DNA data from services like 23andMe, AncestryDNA, or whole-genome sequencing (VCF files) to identify genetic variants associated with Kidney Stones. The analysis is performed entirely in your browser, meaning your genetic data never leaves your device.
For each relevant variant, GenomeInsight reports your genotype, the associated risk allele, the odds ratio from published research, and your overall risk profile compared to the general population. Results are presented with easy-to-understand risk visualizations and percentile rankings.
Genetic risk is only one piece of the puzzle. Lifestyle, diet, environment, and family history all contribute to overall risk. GenomeInsight's analysis is for informational and educational purposes and is not a medical diagnosis.
Understanding Your Kidney Stones Results
After uploading your DNA file, you will receive a detailed health risk report covering 52 conditions, including Kidney Stones. For each condition, GenomeInsight analyzes multiple SNPs (single nucleotide polymorphisms) and calculates a combined risk assessment.
Your results will show whether you carry risk-increasing or protective alleles in genes like CLDN14, SLC7A9, ALPL, and UMOD. Risk levels range from "Below Average" to "Significantly Increased," with population percentile comparisons to contextualize your results.
Frequently Asked Questions About Kidney Stones
Which genes are linked to Kidney Stones?
Kidney Stones has been associated with CLDN14, SLC7A9, ALPL, UMOD in genome-wide association studies. No single variant causes the condition — genetic susceptibility is the sum of many small effects.
If I carry risk variants, will I develop Kidney Stones?
Carrying risk alleles raises probability, not certainty. Most common conditions arise from genes interacting with lifestyle and environment over decades, so a higher genetic risk score is best used as motivation for the relevant screening and prevention measures, not as a prediction.
What DNA data do I need for this analysis?
Any standard consumer-genetics raw file (23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA, or VCF from sequencing) contains the relevant variants. Analysis runs locally on your device, so your genetic data stays private.
Related Conditions That Share These Genes
Variants in the same genes often influence more than one condition. These conditions overlap genetically with Kidney Stones:
Sources & Further Reading
The risk associations described on this page come from published genome-wide association studies and curated public genomic databases. Explore the primary sources for each gene:
Explore Related Conditions
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Discover Your Kidney Stones Risk Profile
Upload your 23andMe, AncestryDNA, or VCF file for a free, privacy-first genetic analysis covering Kidney Stones and 51 other health conditions.
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